What is LSL™ Liposomal Technology
Liposomal technology new? Definitely not! Liposomal technology has been studied since the 1960s. There are many studies* to be found, especially in the medical world. However, development does not stand still. After the successful application in the pharmaceutical industry, you also see more and more liposomal products in the food supplement market.
The challenge we face with regular vitamins and minerals is absorption and bioavailability in the body. Various studies show that regular supplements are absorbed into the blood between 10% and 80%, in the end, less than 5% ends up in the body cells. For optimal bioavailability, it is important that the active ingredients actually arrive in the cells. Using liposomal technology offers a solution!
The dual action of liposomal products allows the active ingredient to arrive in the cells unharmed. Subsequently, the liposomes will fuse with the cell wall and the ingredient will be released into the body cell.
What is a Liposome?
A liposome is a microscopic hollow ‘fat globule’ that is protected by one or more membranes that always consists of a double layer of phospholipids.
A phospholipid can be recognised by a hydrophilic head (water soluble) and a hydrophobic tail (water repellent). The cavity can be filled with active substances from medicines and/or nutrients through a complex process. These liposomes are then used as a means of transport to transport active substances in the body, so that they can reach the cells intact. As soon as liposomes come into contact with a cell membrane, the liposome fuses with the wall, as it were, and the active substances are released into the cell.
What makes our LSL™ LIPOSOMAL TECHNOLOGY so special?
Liposomal technology ensures that the active substances of vitamins, minerals and botanicals, among other things, are better absorbed by the gastrointestinal tract. Regular dietary supplements have the disadvantage that complex molecules (partly) break down the active substances, so that the body cannot absorb them properly.
By applying liposomal technology, this barrier is broken. The ingredients are protected because they are, as it were, ‘wrapped’ in the liposomes and are transported through the body to the cells. This ensures better absorption and the highest possible bioavailability of the ingredients.
What makes our LSL™ Liposomal Technology so special? The process of developing true liposomal powders is incredibly complex. A true liposome is composed of a lipid double layer. Due to this necessary double layer, the ingredient is optimally protected and transported through the body.
Different sizes of liposomes
An important part of optimally functioning liposomes is the size of the liposomes concerned. This is not the same for every product/ingredient. For this reason, each LSL™ product has a different liposome size. Our liposomal technology is therefore distinguished by the fact that each liposomal composition is tailored to the active ingredient. This is the only way it is possible to develop a liposomal powder with the highest possible bioavailability.
Maximum Encapsulation Percentage
Not only the size of the liposomes is therefore important for the quality, but also the encapsulation percentage. By the encapsulation percentage we mean the percentage of the number of liposomes that are actually filled. Lipo Science Laboratory strives for an encapsulation rate of at least 50%. Since this is an extremely important aspect to determine the quality, let’s further investigate the encapsulation percentage using a high performance liquid chromatography (HPLC). We do this in collaboration with the Universiteit van Aken. This is the only way we can guarantee the highest possible bioavailability. It is good to know that the average encapsulation percentage is only 20%.
Excellent quality liposomes
Only the best is good enough. With our mission: “Making health accessible to everyone – today and in the future” is our responsibility to bring only high-quality and effective products to the market. Everything that leaves our laboratory is guaranteed top quality. To substantiate the quality of our products, Lipo Science Laboratory collaborates intensively with various researchers, doctors and independent universities.
All LSL products are extensively analysed by Aachen University (RWTH). Research is done into the quality of our products using a Ciryl-Kryo electron microscope. We combine health with the knowledge from Science. That is why we think it is so important that we can demonstrate that all LSL products are truly liposomal.
This is made possible by the research of Aachen University (RWTH). The liposomal product is frozen during the investigation with the Ciryl-Kryo electron microscope. The advantage of this is that active ingredients can no longer move. This allows clear photos to be taken, so that the team can properly assess the quality. In this research, the focus is mainly on the size of the liposome and/or whether this size is appropriate for the product.
An important quality aspect is the stability of the products, which we check under the transmission electron microscope (TEM). As is generally known, the basis of a liposomal powder always consists of a liquid variant. A sample of the liquid base is kept from each batch. This sample is used to assess the stability. To constantly guarantee our quality, we have each batch examined separately.
It is our mission to: “Make health accessible to everyone – Today and in the future”
Benefits of
LSL-Liposomal powders
At Lipo Science Laboratory, we strive to develop only effective and high-quality liposomal powders. Before a new product is introduced, we have invested a lot in multiple studies and bio-techniques.
Lipo Science Laboratory distinguishes itself from other production processes because our nutrients remain intact in the liposome, are 100% pure and nautral and the nutrientsubstances always remain intact until the colon . A unique aspect of our liposomal technology is that each formulation is always tailored to the active ingredient. This is the only way it is possible to develop a true liposomal powder with the highest possible bioavailability.
Our Benefits
- Optimal transport function;
- Ultimate protection by the liposome;
- Highest bioavailability;
- Pure quality, neutral taste and long shelf life;
- Proven quality*
*Proven Quality
Research has shown that there are a lot of liposomal products for sale that are not fully liposomal. A liposome can be recognized by its spherical structure with a double phospholipid layer. We have investigated various ‘liposomal’ powders brands. Unfortunately, it has been found that there are very few genuine liposomal products on the market.
Our tests have shown that many brands offer micelles (single layer, lower bioavailability), which they then introduce to the market under the name ‘liposomal’. This is possible because the term“Liposomal” is not yet protected in Europe. Although micelles are better absorbed than regular supplements, the absorption and bioavailability is significantly lower than real liposomal supplements.
At Lipo Science Laboratory we see it as our responsibility to develop pure and real liposomal products. Studies by the University of Aachen have also proven that our LSL products actually are liposomal.
Please download the LSL-VitCLip™ studies of the University Aachen of our unique highest bio availability. More info, please contact us.
Facts about liposomes
Shade CW. Liposomes as Advanced Delivery Systems for Nutraceuticals. Integr Med (Encinitas). 2016 Mar;15(1):33-6. PMID: 27053934; PMCID: PMC4818067.
Gopi S, Balakrishnan P. Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. J Liposome Res. 2021 Dec;31(4):356-364. doi: 10.1080/08982104.2020.1820521. Epub 2020 Oct 6. PMID: 32901526.
Shah S, Dhawan V, Holm R, Nagarsenker MS, Perrie Y. Liposomes: Advancements and innovation in the manufacturing process. Adv Drug Deliv Rev. 2020;154-155:102-122. doi: 10.1016/j.addr.2020.07.002. Epub 2020 Jul 8. PMID: 32650041.
Franzé S, Selmin F, Samaritani E, Minghetti P, Cilurzo F. Lyophilization of Liposomal Formulations: Still Necessary, Still Challenging. Pharmaceutics. 2018 Aug 28;10(3):139. doi: 10.3390/pharmaceutics10030139. PMID: 30154315; PMCID: PMC6161153.